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Long-term administration of corticosteroids in myasthenia gravis

From the Department of Neurology, University of Virginia Medical Center, Charlottesville.

Favorable results were obtained in 30 patients with myasthenia gravis treated initially with high daily doses of prednisone and subsequently maintained on lower doses for a protracted period. In 45 incidents of treatment, complete remission occurred in 69 percent, marked improvement in 20 percent, and moderate improvement in 7 percent. Nineteen patients proceeded to thymectomy, with negligible morbidity and sustained improvement. In four patients, it was possible to discontinue prednisone 1 year or more after thymectomy.

Requests for reprints should be addressed to Dr. Johns, Department of Neurology, University of Virginia Medical Center, Charlottesville, VA22901.

This study was supported in part by NINCDS training grant NB-5120 and Muscular Dystrophy Associations of America, Inc., and the Clinical Research Unit was supported by USPHS grant No. RR847.

Presented in part at the twenty-fourth annual meeting of the American Academy of Neurology, St. Louis, April 1972.

Received for publication August 26, 1975.