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NEUROLOGY 1976;26:273
© 1976 American Academy of Neurology

Spontaneous recurrent seizure state induced by daily electric amygdaloid stimulation in Senegalese baboons (Papio papio)

JUHN A. WADA, M.D., Med.Sc.D., F.R.C.P. (C) and TAKESHI OSAWA, M.D., Med.Sc.D.

From the Division of Neurological Sciences, Faculty of Medicine, University of British Columbia, Vancouver, Canada.

Daily electrical stimulation of the amygdala in Senegalese baboons (Papio papio) resulted in the development of generalized convulsive seizures of focal onset through five distinct clinical stages in an average of 72 days. The chronologic pattern of electroclinical features suggested that vertical intrahemispheric ictal dissemination was of primary importance in the progressive seizure development. Some animals developed spontaneous recurrence of both partial complex and primary generalized seizures. The kindling preparation in P. papio represents a unique model of human epilepsy with its secondary generalized convulsive seizure development, spontaneously recurrent partial and primary generalized seizures in the background of predisposed epileptogenic susceptibility.

Dr. Wada's address is Health Sciences Center Hospital, University of British Columbia, Vancouver, B.C. V6T 1W5, Canada.

A preliminary report of this study was presented at the 28th annual meeting of the American EEG Society, Seattle, June 1974.

This study was aided by grants awarded to J.A.W. from the Canadian MRC, Ottawa, Ontario and the NINCDS, Bethesda, Maryland.

Received for publication July 14, 1975.






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