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Thalamic neuroaxonal dystrophy and dementia in Hodgkin's disease

From the Departments of Neurology and Pathology (Neuropathology), Mount Sinai Hospital Medical Center, Chicago; and Neurology Service, Veterans Administration Hospital, Hines, Illinois.

The brain of a patient with Hodgkin's disease and dementia showed numerous dystrophic axons in the thalamus. In absence of lymphomatous cellular infiltration, necrosis, hemorrhage, demyelination, neuronal loss, or infection by opportunistic organisms, the axonal dystrophy in this patient appeared to be directly related to the Hodgkin's disease itself. Moreover, dementia as a nonmetastatic complication of Hodgkin's disease may have been the result of the thalamic axonal dystrophy.

Dr. Reyes address is Department of Neurology, Mount Sinai Hospital Medical Center, California Avenue at 15th Street, Chicago, IL 60608.

Received for publication June 19, 1975.