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NEUROLOGY 1976;26:221
© 1976 American Academy of Neurology

Calcification of the basal ganglia as a cause of levodopa-resistant parkinsonism

HAROLD L. KLAWANS, M.D., MARK LUPTON, M.D. and LAURA SIMON, M.D.

From the Division of Neurology and Division of Endocrinology and Metabolism, Michael Reese Hospital and Medical Center, and the Department of Medicine, University of Chicago Pritzker School of Medicine, Chicago, Illinois.

We present a patient with levodopa-resistant parkinsonism due to basal ganglia calcification related to surgically-induced hypoparathyroidism. The calcification was seen on computerized axial tomography but not on skull x-rays. Such calcification should be looked for in all cases of levodopa-resistant parkinsonism, since it is possible that treatment of hypoparathyroidism may halt progression of the disease. This case with similar ones from the literature suggest that striatal disease itself can cause parkinsonism and that the parkinsonism in such patients tends to be less responsive or nonresponsive to levodopa.

Dr. Klawans' address is Division of Neurology, Michael Reese Medical Center, 29th St. and Ellis Ave., Chicago, IL 60616.

This work was supported in part by the United Parkinson Foundation, Michael Reese Medical Research Institute Council, and the Boothroyd Foundation, Chicago, Illinois.

Presented in part at the annual meeting of the American Academy of Neurology, Miami, Florida, 1975.

Received for publication July 28, 1975.






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