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NEUROLOGY 1976;26:99
© 1976 American Academy of Neurology

Biochemical and histochemical studies of biogenic amines in spinal cord trauma

JUSTIN A. ZIVIN, M.D., Ph.D., JOHN L. DOPPMAN, M.D., JOHN L. REID, M.D., MARCEL L. TAPPAZ, Ph.D., JUAN M. SAAVEDRA, M.D., IRWIN J. KOPIN, M.D. and DAVID M. JACOBOWITZ, Ph.D.

From the Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland, the Department of Neurology, University of California, Third and Parnassus, San Francisco, California (Dr. Zivin), the Department of Diagnostic Radiology, Clinical Center, National Institute of Health, Bethesda, Maryland (Dr. Doppman), and the Royal Postgraduate Medical School, University of London, Hammersmith Hospital, Ducane Road, London W12, OHS England (Dr. Reid).

Highly sensitive enzymatic assays, microdissection techniques, and histochemical methods were used to investigate the effects of blunt trauma on rabbit spinal cord serotonin, norepinephrine, and dopamine concentrations. Within 5 minutes after trauma, norepinephrine and serotonin in gray matter decreased considerably at the lesion center. In white matter, norepinephrine decreased or was unchanged, but at the lesion edges serotonin increased. No changes in dopamine concentration were detected. Substantial changes in monoamines do occur after spinal cord trauma and serotonin may play a role in injury development.

Requests for reprints should be addressed to Dr. Zivin, Laboratory of Clinical Science, National Institute of Mental Health, Bldg. 10, Rm. 2D-46, Bethesda, MD 20014.

Received for publication June 23, 1975.






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