Neurology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Correspondence:
Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when Correspondence are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by LINDSTROM, J. M.
Right arrow Articles by DUANE, D. D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by LINDSTROM, J. M.
Right arrow Articles by DUANE, D. D.
NEUROLOGY 1976;26:1054
© 1976 American Academy of Neurology

Antibody to acetylcholine receptor in myasthenia gravis

Prevalence, clinical correlates, and diagnostic value

JON M. LINDSTROM, Ph.D., MARJORIE E. SEYBOLD, M.D., VANDA A. LENNON, M.D., Ph.D., SENGA WHITTINGHAM, M.D. and DRAKE D. DUANE, M.D.

From The Salk Institute for Biological Studies, San Diego (Dr. Lindstrom and Dr. Lennon); Veterans Administration Hospital and University of California, San Diego (Dr. Seybold); Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia (Dr. Whittingham); and the Mayo Clinic and Medical School, Rochester, Minnesota (Dr. Duane).

Elevated amounts of antibodies specific for acetylcholine receptors were detected in 87 percent of sera from 71 patients with myasthenia gravis but not in 175 sera from individuals without myasthenia gravis, including those with other neurologic or autoimmune diseases. Antireceptor antibodies were not directed at the acetylcholine binding site of the receptor. Presence or titer of antibody did not appear to correlate with age, sex, steroid therapy, or duration of symptoms. Myasthenia gravis patients with only ocular symptoms had lower antibody titers, while the majority of titers in myasthenia gravis patients with thymoma exceeded the median titer of the myasthenia gravis group as a whole. Assay of antireceptor antibody should prove a useful test in the diagnosis of myasthenia gravis.

Reprint requests should be addressed to Dr. Lindstrom, The Salk Institute for Biological Studies, PO Box 1909, San Diego, CA 92112.

This work was supported by grants from the National Institutes of Health, the Muscular Dystrophy Association of America, and the California Chapter of the Myasthenia Gravis Foundation.

Received for publication October 20, 1975.




This article has been cited by other articles:


Home page
 Arch NeurolHome page
S. Ragheb, R. Lisak, R. Lewis, G. Van Stavern, F. Gonzales, and K. Simon
A Potential Role for B-Cell Activating Factor in the Pathogenesis of Autoimmune Myasthenia Gravis
Arch Neurol, October 1, 2008; 65(10): 1358 - 1362.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
J. Lindstrom
'Seronegative' myasthenia gravis is no longer seronegative
Brain, July 1, 2008; 131(7): 1684 - 1685.
[Full Text] [PDF]

Home page
 BloodHome page
A. Gilboa-Geffen, P. P. Lacoste, L. Soreq, G. Cizeron-Clairac, R. Le Panse, F. Truffault, I. Shaked, H. Soreq, and S. Berrih-Aknin
The thymic theme of acetylcholinesterase splice variants in myasthenia gravis
Blood, May 15, 2007; 109(10): 4383 - 4391.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
L. Liu, A. M. Garcia, H. Santoro, Y. Zhang, K. McDonnell, J. Dumont, and A. Bitonti
Amelioration of Experimental Autoimmune Myasthenia Gravis in Rats by Neonatal FcR Blockade
J. Immunol., April 15, 2007; 178(8): 5390 - 5398.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
E. Bartoccioni, F. Scuderi, G. M. Minicuci, M. Marino, F. Ciaraffa, and A. Evoli
Anti-MuSK antibodies: Correlation with myasthenia gravis severity
Neurology, August 8, 2006; 67(3): 505 - 507.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
S. Vernino
Neurologic autoantibodies: Cautious enthusiasm
Neurology, December 13, 2005; 65(11): 1688 - 1689.
[Full Text] [PDF]

Home page
 J. Exp. Biol.Home page
A. L. Obaid, M. E. Nelson, J. Lindstrom, and B. M. Salzberg
Optical studies of nicotinic acetylcholine receptor subtypes in the guinea-pig enteric nervous system
J. Exp. Biol., August 1, 2005; 208(15): 2981 - 3001.
[Abstract] [Full Text] [PDF]

Home page
 J Intensive Care MedHome page
N. Natarajan and R. Weinstein
Therapeutic Apheresis in Neurology Critical Care
J Intensive Care Med, July 1, 2005; 20(4): 212 - 225.
[Abstract] [PDF]

Home page
 Hum Reprod UpdateHome page
D. Goswami and G. S. Conway
Premature ovarian failure
Hum. Reprod. Update, July 1, 2005; 11(4): 391 - 410.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. Poea-Guyon, P. Christadoss, R. Le Panse, T. Guyon, M. De Baets, A. Wakkach, J. Bidault, S. Tzartos, and S. Berrih-Aknin
Effects of Cytokines on Acetylcholine Receptor Expression: Implications for Myasthenia Gravis
J. Immunol., May 15, 2005; 174(10): 5941 - 5949.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurol. Neurosurg. PsychiatryHome page
Y Nemoto, S Kuwabara, S Misawa, N Kawaguchi, T Hattori, M Takamori, and A Vincent
Patterns and severity of neuromuscular transmission failure in seronegative myasthenia gravis
J. Neurol. Neurosurg. Psychiatry, May 1, 2005; 76(5): 714 - 718.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
P. Nancy and S. Berrih-Aknin
Differential Estrogen Receptor Expression in Autoimmune Myasthenia Gravis
Endocrinology, May 1, 2005; 146(5): 2345 - 2353.
[Abstract] [Full Text] [PDF]

Home page
 JAMAHome page
K. Scherer, R. S. Bedlack, and D. L. Simel
Does This Patient Have Myasthenia Gravis?
JAMA, April 20, 2005; 293(15): 1906 - 1914.
[Abstract] [Full Text] [PDF]

Home page
 Postgrad. Med. J.Home page
B R Thanvi and T C N Lo
Update on myasthenia gravis
Postgrad. Med. J., December 1, 2004; 80(950): 690 - 700.
[Abstract] [Full Text] [PDF]

Home page
 JAOA: Journal of the American Osteopathic AssociationHome page
M. J. Kothari
Myasthenia Gravis
J Am Osteopath Assoc, September 1, 2004; 104(9): 377 - 384.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
D. Selcen, T. Fukuda, X.-M. Shen, and A. G. Engel
Are MuSK antibodies the primary cause of myasthenic symptoms?
Neurology, June 8, 2004; 62(11): 1945 - 1950.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurol. Neurosurg. PsychiatryHome page
A Vincent, L Clover, C Buckley, J G. Evans, and P M Rothwell
Evidence of underdiagnosis of myasthenia gravis in older people
J. Neurol. Neurosurg. Psychiatry, August 1, 2003; 74(8): 1105 - 1108.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
A. Abicht and H. Lochmuller
What's in the serum of seronegative MG and LEMS?: MuSK et al.
Neurology, December 10, 2002; 59(11): 1672 - 1673.
[Full Text] [PDF]

Home page
 J. Neurosci.Home page
F. Ono, A. Shcherbatko, S.-i. Higashijima, G. Mandel, and P. Brehm
The Zebrafish Motility Mutant twitch once Reveals New Roles for Rapsyn in Synaptic Function
J. Neurosci., August 1, 2002; 22(15): 6491 - 6498.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. Reyes-Reyna, T. Stegall, and K. A. Krolick
Muscle Responds to an Antibody Reactive with the Acetylcholine Receptor by Up-Regulating Monocyte Chemoattractant Protein 1: A Chemokine with the Potential to Influence the Severity and Course of Experimental Myasthenia Gravis
J. Immunol., August 1, 2002; 169(3): 1579 - 1586.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
H. Itoh, K. Shibata, and S. Nitta
Sensitivity to Vecuronium in Seropositive and Seronegative Patients with Myasthenia Gravis
Anesth. Analg., July 1, 2002; 95(1): 109 - 113.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
J. Ricny, L. Simkova, and A. Vincent
Determination of Anti-Acetylcholine Receptor Antibodies in Myasthenic Patients by Use of Time-resolved Fluorescence
Clin. Chem., March 1, 2002; 48(3): 549 - 554.
[Abstract] [Full Text] [PDF]

Home page
 Br J AnaesthHome page
H. Itoh, K. Shibata, and S. Nitta
Difference in sensitivity to vecuronium between patients with ocular and generalized myasthenia gravis
Br. J. Anaesth., December 1, 2001; 87(6): 885 - 889.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
M. Giraud, G. Beaurain, A. M. Yamamoto, B. Eymard, C. Tranchant, P. Gajdos, and H.-J. Garchon
Linkage of HLA to myasthenia gravis and genetic heterogeneity depending on anti-titin antibodies
Neurology, November 13, 2001; 57(9): 1555 - 1560.
[Abstract] [Full Text] [PDF]

Home page
 Arch NeurolHome page
A. M. Yamamoto, P. Gajdos, B. Eymard, C. Tranchant, J.-M. Warter, L. Gomez, C. Bourquin, J.-F. Bach, and H.-J. Garchon
Anti-Titin Antibodies in Myasthenia Gravis: Tight Association With Thymoma and Heterogeneity of Nonthymoma Patients
Arch Neurol, June 1, 2001; 58(6): 885 - 890.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
S. ARAGA, L. XU, K. NAKASHIMA, M. VILLAIN, and J. E. BLALOCK
A peptide vaccine that prevents experimental autoimmune myasthenia gravis by specifically blocking T cell help
FASEB J, January 1, 2000; 14(1): 185 - 196.
[Abstract] [Full Text]

Home page
 NeurologyHome page
S. Vernino, R. G. Auger, A. M. Emslie-Smith, C. M. Harper, and V. A. Lennon
Myasthenia, thymoma, presynaptic antibodies, and a continuum of neuromuscular hyperexcitability
Neurology, October 1, 1999; 53(6): 1233 - 1233.
[Abstract] [Full Text]

Home page
 Hum ReprodHome page
S.N. Kalantaridou, D.T. Braddock, N.J. Patronas, and L.M. Nelson
Treatment of autoimmune premature ovarian failure: Case report
Hum. Reprod., July 1, 1999; 14(7): 1777 - 1782.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
B. Ferrero, G. Aimo, R. Pagni, B. Bergamasco, M. R. Bongioanni, L. Bergamini, and L. Durelli
Modified and improved anti-acetylcholine receptor (AChR) antibody assay: comparison of analytical and clinical performance with conventional anti-AChR antibody assay
Clin. Chem., May 1, 1997; 43(5): 824 - 831.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
N. Moulian, J. Bidault, F. Truffault, A. M. Yamamoto, P. Levasseur, and S. Berrih-Aknin
Thymocyte Fas Expression Is Dysregulated in Myasthenia Gravis Patients With Anti-Acetylcholine Receptor Antibody
Blood, May 1, 1997; 89(9): 3287 - 3295.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
D. B. Drachman
Myasthenia Gravis
N. Engl. J. Med., June 23, 1994; 330(25): 1797 - 1810.
[Full Text]

Home page
 J Child NeurolHome page
A. K. Afifi and W. E. Bell
Tests for Juvenile Myasthenia Gravis: Comparative Diagnostic Yield and Prediction of Outcome
J Child Neurol, October 1, 1993; 8(4): 403 - 411.
[Abstract] [PDF]

Home page
 J Child NeurolHome page
J. Z. Heckmatt, M. Placzek, A. H. Thompson, V. Dubowitz, and G. Watson
An Unusual Case of Neonatal Myasthenia
J Child Neurol, January 1, 1987; 2(1): 63 - 66.
[Abstract] [PDF]

Home page
 J Child NeurolHome page
C. K. Jablecki
Review Article: Electromyography in Infants and Children
J Child Neurol, October 1, 1986; 1(4): 297 - 318.
[Abstract] [PDF]

Home page
 ScienceHome page
K. McIntosh and D. Drachman
Induction of suppressor cells specific for AChR in experimental autoimmune myasthenia gravis
Science, April 18, 1986; 232(4748): 401 - 403.
[Abstract] [PDF]

Home page
 ScienceHome page
B. Conti-Tronconi, C. Gotti, M. Hunkapiller, and M. Raftery
Mammalian muscle acetylcholine receptor: a supramolecular structure formed by four related proteins
Science, December 17, 1982; 218(4578): 1227 - 1229.
[Abstract] [PDF]

Home page
 Arch SurgHome page
J. C. Heiser, R. B. Rutherford, and S. P. Ringel
Thymectomy for Myasthenia Gravis: A Changing Perspective
Arch Surg, May 1, 1982; 117(5): 533 - 537.
[Abstract] [PDF]

Home page
 Arch NeurolHome page
J. Keesey, F. Naiem, J. Lindstrom, D. Roe, C. Herrmann Jr, and R. Walford
Acetylcholine Receptor Antibody Titer and HLA-B8 Antigen in Myasthenia Gravis
Arch Neurol, February 1, 1982; 39(2): 73 - 77.
[Abstract] [PDF]

Home page
 ScienceHome page
E. Stanley and D. Drachman
Effect of myasthenic immunoglobulin on acetylcholine receptors of intact mammalian neuromuscular junctions
Science, June 16, 1978; 200(4347): 1285 - 1287.
[Abstract] [PDF]

Home page
 ScienceHome page
I Kao and D. Drachman
Myasthenic immunoglobulin accelerates acetylcholine receptor degradation
Science, April 29, 1977; 196(4289): 527 - 529.
[Abstract] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1976 by AAN Enterprises, Inc.