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NEUROLOGY 1976;26:84
© 1976 American Academy of Neurology

A heat-stable blocking factor in the plasma of patients with subacute sclerosing panencephalitis

HERBERT M. SWICK, M.D., WILLIAM H. BROOKS, M.D., THOMAS L. ROSZMAN, Ph.D. and DAVID CALDWELL, M.S.

From the Departments of Neurology, Neurosurgery, and Cell Biology, University of Kentucky Medical Center, and the Veterans Administration Hospital, Lexington, Kentucky.

The possible role of a defective cell-mediated immune response in the pathogenesis of subacute sclerosing panencephalitis remains unclear. Cell-mediated immunity has been investigated in nine patients with this disorder. In eight patients, a heat-stable blocking factor in the plasma inhibited normal lymphocyte transformation to phytohemagglutinin and mixed lymphocyte cultures. The degree of blocking increased as the disease progressed. The nature of the blocking factor is unknown and is currently under investigation. A heat-stable blocking factor has not been described previously in subacute sclerosing panencephalitis, although a heat-labile blocking factor has been reported in a total of five patients.

Reprint requests should be addressed to Dr. Swick at Milwaukee Children's Hospital, 1700 W. Wisconsin Ave., Milwaukee, WI 53233.

Presented at the annual meeting of the Child Neurology Society, Madison, Wisconsin, October 1974.

This investigation was supported in part by Special Traineeship Award 1-F11-NSO 2463, National Institute of Neurological Diseases and Stroke, National Institutes of Health, and by the Veterans Administration.

Received for publication March 24, 1975.






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