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Neuropathology of Huntington's chorea

Studies of the ventrobasal complex of the thalamus

From the laboratory "Cytology of the Nervous System," Psychiatric Centre St. Kamillus, University of Louvain, Bierbeek, Belgium.

In seven cases of Huntington's chorea, the ventrolateral thalamus was studied by quantitative cytometry. A selective 50 percent atrophy of microneurons (internuncial cells) was found while the macroneurons did not show significant atrophy. Thalamic microneurons might be presynaptic and postsynaptic inhibitory cells. Their specific atrophy in Huntington's chorea thus could be related to the known decrease of gamma aminobutyric acid (GABA) in Huntington's chorea.

Dr. Dom's address is Laboratory "Cytology of the Nervous System," Psychiatric Centre St. Kamillus, University of Louvain, Krijkelberg 1-3043 Bierbeek, Belgium.

Supported by a grant from the Steunfonds voor chronische ziekten and from N.F.W.O., Belgium.

Received for publication February 3, 1975.

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