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Viruslike particles in muscle from a patient with amyotrophic lateral sclerosis

From the Viral and Rickettsial Disease Laboratory, California State Department of Health, Berkeley (Drs. Oshiro, Cremer, and Lennette), and the Institutes of Medical Sciences, San Francisco (Dr. Norris).

An electron microscopic study of muscle and central nervous tissues from a case of amyotrophic lateral sclerosis showed crystalline arrays of 20 to 24 nm viruslike particles in muscle. The particles were located between the myofibrils, adjacent to the Z bands, and near the perinuclear region, but were never seen within the nucleus. Cell cultures from the same muscle specimens showed no such particles. Central nervous system tissues and cultures also failed to show viruslike particles. The cultures were negative by the indirect fluorescent antibody technique with serums from patients with amyotrophic lateral sclerosis. The nature of these particles or their relationship to amyotrophic lateral sclerosis is unknown.

Dr. Lennette's address is Biomedical Laboratories, State of California-Department of Health, 2151 Berkeley Way, Berkeley, CA 94704.

This investigation was supported by Public Health Service grants AI08200 and AI-01475 from the National Institute of Allergy and Infectious Diseases, National institutes of Health, and a grant from the C. E. Merrill Trust.

Received for publication March 26, 1975.

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