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Gamma hydroxybutyrate

Correlation of serum and cerebrospinal fluid levels with electroencephalographic and behavioral effects

From the Departments of Pediatrics and Neurology, Yale University School of Medicine and Yale-New Haven Hospital, New Haven, Connecticut, and the Departments of Pediatrics and Neurology, University of Chicago, Chicago, Illinois.

Gamma hydroxybutyrate was administered to adult cats by intravenous infusion at varying dosages while an electroencephalogram (EEG) was recorded from electrodes placed stereotactically in the right and left hippocampus and thalamic intralaminar nucleus and from cortical electrodes. Blood and cerebrospinal fluid samples were assayed for gamma hydroxybutyrate. The first EEG change, slowing with occasional spikes, was seen at serum levels of 75 µg per milliliter. Changes in the recordings progressed through a number of stages, culminating in bursts of poly spiking interspersed among periods of electrical silence first seen at 350 µg per milliliter. Behavior was characterized by a progressively deepening trancelike state punctuated at higher serum levels by spontaneous and stimulus-induced myoclonic jerks. These changes were correlated with serum levels and are more similar to petit mal stupor than any kind of natural sleep-like state previously used to describe them

Requests for reprints should be addressed to Dr. Huttenlocher, Department of Pediatrics, University of Chicago, Chicago, IL 60637.

Presented in part at the twenty-seventh annual meeting of the American Academy of Neurology, Bal Harbour, FL, May 1975.

This work is supported in part by U.S. Public Health Service grant NS 06208, and the Esther A. and Joseph Klingenstein Fund.

Received for publication May 30, 1975.

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