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Studies in myasthenia gravis

Pyridostigmine-C¹⁴ metabolism after thymectomy

Departments of Medicine, Pharmacology, Neurology, and Surgery and the Myasthenia Gravis Clinic and Research Laboratory, the Mount Sinai School of Medicine of the City University of New York, New York City.

Pyridostigmine-carbon14 (P-C¹⁴) excretion studies in myasthenia gravis patients who had had thymectomies failed to produce any significant difference from results observed in myasthenic patients who had not had thymectomies. Thus, change in P-C¹⁴ metabolism cannot help explain decreased anticholinesterase requirements and electromyographic changes observed in some patients following thymectomy.

Supported in part by NIH Grant PR-00071, Division of Research Resources, General Clinical Research Center Branches and by a Research Grant from Hoffmann-La Roche Inc.

Received for publication December 6, 1974.

Dr. Kornfeld's address is 853 Fifth Ave., New York, NY 10021.