HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Correspondence: Submit a response Alert me when this article is cited Alert me when Correspondence are posted Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by INGVAR, O. H. Articles by SCHWARTZ, M. S. Search for Related Content PubMed PubMed Citation Articles by INGVAR, O. H. Articles by SCHWARTZ, M. S.

Evidence of subnormal function of association cortex in presenile dementia

Department of Clinical Neurophysiology, University Hospital, Lund, Sweden.

Regional cerebral blood flow (rCBF) was measured in 23 patients with organic dementia (17 patients with Alzheimer's disease and six with low-pressure hydrocephalus [LPH]). The flow of gray matter was significantly reduced, especially in occipito-parieto-temporal regions, as well as frontally in some patients. During activation with psychologic tests, reading, etc., the flow augmentation in the association areas in the demented patients was not as marked as in nondemented controls. Instead, in some patients, a flow diminution was recorded in the same regions (intellectual steal). Organic dementia appears to be accompanied by a low activity in the association cortex and a reduced ability to activate these regions during mental effort.

This study was supported by the Swedish Medical Research Council (projects B73-14X-84-09A and B74-14X-84-10B), the Swedish Council for Social Science Research, the Wallenberg and the Thuring Foundations in Stockholm, and the Konsul Thure Carlsson Foundation in Silvesborg.

Received for publication December 27, 1974.

Dr. Ingvar's address is Department of Clinical Neurophysiology, University Hospital, Lund, Sweden.

This article has been cited by other articles:

				K. M. Bradley, V. T. O'Sullivan, N. D. W. Soper, Z. Nagy, E. M.-F. King, A. D. Smith, and B. J. Shepstone Cerebral perfusion SPET correlated with Braak pathological stage in Alzheimer's disease Brain, August 1, 2002; 125(8): 1772 - 1781. [Abstract] [Full Text] [PDF]