HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Correspondence: Submit a response Alert me when this article is cited Alert me when Correspondence are posted Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by SERCOMBE, R. Articles by SEYLAZ, J. Search for Related Content PubMed PubMed Citation Articles by SERCOMBE, R. Articles by SEYLAZ, J.

Neurogenic influence on local cerebral blood flow

Effect of catecholamines or sympathetic stimulation as correlated with the sympathetic innervation

Laboratoire de Neuro-Physio-Pathologie Humaine, Service de Neurochirurgie, Høpital Lariboisiere, Paris, France, and the Department of Histology, University of Lund, Lund, Sweden.

Local cerebral blood flow was measured continuously in conscious rabbits (thermoclearance technique), and PaO₂ and PaCO₂ were recorded by mass spectrometry. Though inhalation of CO₂ increased flow in caudate nucleus and lateral geniculate body, catecholamines only had effect on caudate nucleus where isoproterenolenhanced and epinephrine and norepinephrine reduced flow. Reduction by electrical stimulation of the neck sympathetic trunk was particularly evident in the caudate. Blood flow increased markedly in both regions after preganglionic conduction blockade. The effects were correlated with a significantly lower degree of sympathetic arteriolar innervation (fluorescence histochemistry) in the lateral geniculate body compared with the caudate nucleus.

This study was supported by grants from the Swedish Medical and Natural Sciences Research Councils (grants No. 04X-732 and R3511-001-007), INSERM (contract No. 7121 588) and CNRS under the auspices of R.C.P. No. 319 and E.R.A. No. 361.

Received for publication February 3, 1975.

Dr. Owman's address is Department of Histology, Biskopsgatan 5, S-223 62 Lund, Sweden.

This article has been cited by other articles:

				P. N Ainslie, J. C Ashmead, K. Ide, B. J Morgan, and M. J Poulin Differential responses to CO2 and sympathetic stimulation in the cerebral and femoral circulations in humans J. Physiol., July 15, 2005; 566(2): 613 - 624. [Abstract] [Full Text] [PDF]

				K. Kawamura and S. Takebayashi Perivascular Innervation of the Cerebral Arteries in Spontaneously Hypertensive Rats An Immunohistochemical Study Angiology, February 1, 1991; 42(2): 123 - 132. [Abstract] [PDF]

				M Lindvall, L Edvinsson, and C Owman Sympathetic nervous control of cerebrospinal fluid production from the choroid plexus Science, July 14, 1978; 201(4351): 176 - 178. [Abstract] [PDF]